{"id":255,"date":"2010-05-09T20:50:17","date_gmt":"2010-05-09T18:50:17","guid":{"rendered":"http:\/\/www.pjh.fr\/wordpress\/?page_id=255"},"modified":"2010-06-18T11:39:24","modified_gmt":"2010-06-18T09:39:24","slug":"vmp-vista","status":"publish","type":"page","link":"http:\/\/www.pjh.fr\/wordpress\/?page_id=255","title":{"rendered":"VMP (Vista)"},"content":{"rendered":"<p><strong>Indications principales :<\/strong><\/p>\n<ul>\n<li>My\u00e9lome 1\u00e8re ligne (patients non \u00e9ligibles \u00e0 une greffe)<\/li>\n<\/ul>\n<h3>CYCLES 1 \u00e0 4 (8 injections de Velcade par cycle)<\/h3>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">BORTEZOMIB<\/span><\/strong><\/td>\n<td style=\"width: 33%;\">VELCADE<\/td>\n<td>1,3 mg\/m<sup>2<\/sup>\/J \u00e0 J1, J4, J8 et J11 puis J22, J25, J29 et J32<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">IVD<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td align=\"center\"><strong>J2<\/strong><\/td>\n<td align=\"center\"><strong>J3<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J13<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J22<\/strong><\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J25<\/strong><\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J29<\/strong><\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J32<\/strong><\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347; text-align: center;\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"text-align: center; background-color: #ff6347;\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">MELPHALAN <\/span><\/strong><\/td>\n<td style=\"width: 33%;\">ALKERAN (cp 2 mg)<\/td>\n<td>9 mg\/m<sup>2<\/sup>\/J de J1 \u00e0 J4<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">Voie orale<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J2<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J3<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J13<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J22<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J25<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J29<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J32<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">PREDNISONE <\/span><\/strong><\/td>\n<td style=\"width: 33%;\">CORTANCYL<\/td>\n<td>60 mg\/m<sup>2<\/sup>\/J de J1 \u00e0 J4<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">Voie orale<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J2<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J3<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J13<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J22<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J25<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J29<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J32<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>CYCLES 5 \u00e0 9 (4 injections de Velcade par cycle)<\/h3>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">BORTEZOMIB<\/span><\/strong><\/td>\n<td style=\"width: 33%;\">VELCADE<\/td>\n<td>1,3 mg\/m<sup>2<\/sup>\/J \u00e0 J1,\u00a0 J8 puis J22, J29<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">IVD<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td align=\"center\"><strong>J2<\/strong><\/td>\n<td align=\"center\"><strong>J3<\/strong><\/td>\n<td align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J13<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">J22<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J25<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">J29<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J32<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347; text-align: center;\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"text-align: center;\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">MELPHALAN <\/span><\/strong><\/td>\n<td style=\"width: 33%;\">ALKERAN (cp 2 mg)<\/td>\n<td>9 mg\/m<sup>2<\/sup>\/J de J1 \u00e0 J4<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">Voie orale<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J2<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J3<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J13<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J22<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J25<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J29<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J32<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"background-color: #d3d3d3; width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td style=\"width: 33%; background-color: #d3d3d3;\"><strong><span style=\"color: #ff0000;\">PREDNISONE <\/span><\/strong><\/td>\n<td style=\"width: 33%;\">CORTANCYL<\/td>\n<td>60 mg\/m<sup>2<\/sup>\/J de J1 \u00e0 J4<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td colspan=\"2\">Voie orale<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J1<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J2<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J3<\/strong><\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\"><strong>J4<\/strong><\/td>\n<td align=\"center\">J5<\/td>\n<td align=\"center\">J6<\/td>\n<td align=\"center\">J7<\/td>\n<td align=\"center\"><strong>J8<\/strong><\/td>\n<td align=\"center\">J9<\/td>\n<td align=\"center\">J10<\/td>\n<td align=\"center\"><strong>J11<\/strong><\/td>\n<td align=\"center\">J12<\/td>\n<td align=\"center\">J23<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J22<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J25<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J29<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\">J32<\/td>\n<td align=\"center\">&#8230;<\/td>\n<td align=\"center\"><strong>J42<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td style=\"background-color: #ff6347;\" align=\"center\">x<\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<td align=\"center\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width: 100%;\" border=\"0\" cellspacing=\"0\" cellpadding=\"2\">\n<tbody>\n<tr style=\"background-color: #d3d3d3;\" valign=\"top\">\n<td style=\"width: 180px;\"><strong>Rythme :<\/strong><\/td>\n<td><strong> J1=J43<\/strong><\/td>\n<\/tr>\n<tr valign=\"top\">\n<td><strong>Dur\u00e9e :<\/strong><\/td>\n<td>9 cycles<\/td>\n<\/tr>\n<tr style=\"background-color: #d3d3d3;\" valign=\"top\">\n<td valign=\"top\"><strong>Traitements associ\u00e9s :<\/strong><\/td>\n<td>\n<ul>\n<li>Anti-naus\u00e9eux : non syst\u00e9matique<strong> <\/strong><\/li>\n<li>Facteurs de croissance h\u00e9matopo\u00ef\u00e9tiques : non syst\u00e9matiques (prophylaxie secondaire)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td><strong>Risque \u00e9m\u00e9tisant : <\/strong><\/td>\n<td>Mod\u00e9r\u00e9<\/td>\n<\/tr>\n<tr style=\"background-color: #d3d3d3;\">\n<td><strong>Alop\u00e9cie :<\/strong><\/td>\n<td>Non<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td><strong>Pr\u00e9cautions :<\/strong><\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr style=\"background-color: #d3d3d3;\" valign=\"top\">\n<td valign=\"top\"><strong>Doses cumul\u00e9es max :<br \/>\n<\/strong><\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td valign=\"top\"><strong>Surveillance :<\/strong><\/td>\n<td>Plaquettes avant les injections de Velcade puis NFS\/15J (avant chaque d\u00e9but de cycle)<br \/>\nMarqueurs du my\u00e9lome : EPP, Ca, Cr\u00e9atinin\u00e9mie +\/- cha\u00eenes l\u00e9g\u00e8res libres etc&#8230;<\/td>\n<\/tr>\n<tr style=\"background-color: #d3d3d3;\" valign=\"top\">\n<td><strong>Co\u00fbt par cycle :<\/strong><\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>R\u00e9f\u00e9rences :<\/strong><\/p>\n<p>San Miguel, J. F., Schlag, R., Khuageva, N. K., Dimopoulos, M. A., Shpilberg, O., Kropff, M., et al. (2008).<a href=\"http:\/\/www.pjh.fr\/refbase\/search.php?sqlQuery=SELECT%20author%2C%20title%2C%20type%2C%20year%2C%20publication%2C%20abbrev_journal%2C%20volume%2C%20issue%2C%20pages%2C%20keywords%2C%20abstract%2C%20address%2C%20corporate_author%2C%20thesis%2C%20publisher%2C%20place%2C%20editor%2C%20language%2C%20summary_language%2C%20orig_title%2C%20series_editor%2C%20series_title%2C%20abbrev_series_title%2C%20series_volume%2C%20series_issue%2C%20edition%2C%20issn%2C%20isbn%2C%20medium%2C%20area%2C%20expedition%2C%20conference%2C%20notes%2C%20approved%2C%20call_number%2C%20serial%20FROM%20refs%20WHERE%20serial%20%3D%2015%20ORDER%20BY%20author%2C%20year%20DESC%2C%20publication&amp;client=&amp;formType=sqlSearch&amp;submit=Display&amp;viewType=&amp;showQuery=0&amp;showLinks=1&amp;showRows=5&amp;rowOffset=&amp;wrapResults=1&amp;citeOrder=&amp;citeStyle=APA&amp;exportFormat=RIS&amp;exportType=html&amp;exportStylesheet=&amp;citeType=html&amp;headerMsg=\" target=\"_blank\"> Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.<\/a> N Engl J Med, 359(9), 906\u2013917.<\/p>\n<p>Mateos, M. &#8211; V., Richardson, P. G., Schlag, R., Khuageva, N. K.,  Dimopoulos, M. A., Shpilberg, O., et al. (2010). <a href=\"http:\/\/www.pjh.fr\/refbase\/search.php?sqlQuery=SELECT%20author%2C%20title%2C%20type%2C%20year%2C%20publication%2C%20abbrev_journal%2C%20volume%2C%20issue%2C%20pages%2C%20keywords%2C%20abstract%2C%20address%2C%20corporate_author%2C%20thesis%2C%20publisher%2C%20place%2C%20editor%2C%20language%2C%20summary_language%2C%20orig_title%2C%20series_editor%2C%20series_title%2C%20abbrev_series_title%2C%20series_volume%2C%20series_issue%2C%20edition%2C%20issn%2C%20isbn%2C%20medium%2C%20area%2C%20expedition%2C%20conference%2C%20notes%2C%20approved%2C%20call_number%2C%20serial%20FROM%20refs%20WHERE%20serial%20%3D%2015%20ORDER%20BY%20author%2C%20year%20DESC%2C%20publication&amp;client=&amp;formType=sqlSearch&amp;submit=Display&amp;viewType=&amp;showQuery=0&amp;showLinks=1&amp;showRows=5&amp;rowOffset=&amp;wrapResults=1&amp;citeOrder=&amp;citeStyle=APA&amp;exportFormat=RIS&amp;exportType=html&amp;exportStylesheet=&amp;citeType=html&amp;headerMsg=\" target=\"_blank\">Bortezomib plus  melphalan and prednisone compared with melphalan and prednisone in  previously untreated multiple myeloma: updated follow-up and impact of  subsequent therapy in the phase III VISTA trial. <\/a><em>J Clin Oncol<\/em>, <em>28<\/em>(13),  2259\u20132266.<br \/>\n<\/p>\n<div class=\"pdf24Plugin-cp\"> \t<form name=\"pdf24Form0\" method=\"post\" action=\"https:\/\/doc2pdf.pdf24.org\/wordpress.php\" target=\"pdf24PopWin\" onsubmit=\"var pdf24Win = window.open('about:blank', 'pdf24PopWin', 'resizable=yes,scrollbars=yes,width=600,height=250,left='+(screen.width\/2-300)+',top='+(screen.height\/3-125)+''); pdf24Win.focus(); if(typeof pdf24OnCreatePDF === 'function'){void(pdf24OnCreatePDF(this,pdf24Win));}\"> \t\t<input type=\"hidden\" name=\"blogCharset\" value=\"Cw1x07UAAA==\" \/><input type=\"hidden\" name=\"blogPosts\" value=\"MwQA\" \/><input type=\"hidden\" name=\"blogUrl\" value=\"yygpKbDS1y8vL9cryMrQSyvSL88vSikoSi0uBgA=\" \/><input type=\"hidden\" name=\"blogName\" value=\"C0gtKs7PS8xR8MovLQLR+WkKjgoeiam5iSX5OfnpmcUlAA==\" \/><input type=\"hidden\" name=\"blogValueEncoding\" value=\"gzdeflate base64\" \/><input type=\"hidden\" name=\"postId_0\" value=\"MzI1BQA=\" \/><input type=\"hidden\" name=\"postTitle_0\" value=\"C\/MNUNAIyywuSdQEAA==\" \/><input type=\"hidden\" name=\"postLink_0\" value=\"yygpKbDS1y8vL9cryMrQSyvSL88vSikoSi0u1rcvSExPjc9MsTUyNQUA\" \/><input type=\"hidden\" name=\"postAuthor_0\" value=\"cylSCMhMzgcA\" \/><input type=\"hidden\" name=\"postDateTime_0\" value=\"MzIwNNA1MNU1sFQwMrAyMLUyNAcA\" \/><input type=\"hidden\" name=\"postContent_0\" value=\"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\" \/> \t\t<a href=\"https:\/\/www.pdf24.org\" target=\"_blank\" title=\"www.pdf24.org\" rel=\"nofollow\"><img src=\"http:\/\/www.pjh.fr\/wordpress\/wp-content\/plugins\/pdf24-post-to-pdf\/img\/pdf_32x32.png\" alt=\"\" border=\"0\" height=\"32\" \/><\/a> \t\t<span class=\"pdf24Plugin-cp-space\">&nbsp;&nbsp;<\/span> \t\t<span class=\"pdf24Plugin-cp-text\">Envoyer l'article en PDF<\/span> \t\t<span class=\"pdf24Plugin-cp-space\">&nbsp;&nbsp;<\/span> \t\t<input class=\"pdf24Plugin-cp-input\" style=\"margin: 0px;\" type=\"text\" name=\"sendEmailTo\" placeholder=\"Entrez l'adresse e-mail\" \/> \t\t<input class=\"pdf24Plugin-cp-submit\" style=\"margin: 0px;\" type=\"submit\" value=\"Envoyer\" \/> \t<\/form> <\/div>","protected":false},"excerpt":{"rendered":"<p>Indications principales : My\u00e9lome 1\u00e8re ligne (patients non \u00e9ligibles \u00e0 une greffe) CYCLES 1 \u00e0 4 (8 injections de Velcade par cycle) BORTEZOMIB VELCADE 1,3 mg\/m2\/J \u00e0 J1, J4, J8 et J11 puis J22, J25, J29 et J32 IVD J1 J2 J3 J4 J5 J6 J7 J8 J9 J10 J11 J12 J13 &#8230; J22 &#8230; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":210,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/255"}],"collection":[{"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=255"}],"version-history":[{"count":27,"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/255\/revisions"}],"predecessor-version":[{"id":273,"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/255\/revisions\/273"}],"up":[{"embeddable":true,"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/210"}],"wp:attachment":[{"href":"http:\/\/www.pjh.fr\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}